N-(4-Chlorophenyl)-1-(5-{[(2-phenylethenyl)sulfonyl]methyl}-1,3,4-oxadiazol-2-yl)methanesulfonamide

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Synthesis of N'-Substituted-2-(5-(4-Chlorophenyl)-1,3,4- oxadiazol-2-ylthio)acetohydrazide Derivatives as Suitable Antibacterial Agents

Purpose: To evaluate antibacterial activity of a series of molecules bearing 1,3,4-oxadiazole and azomethine moieties. Methods: The 4-chlorobenzoic acid (1) was precursor to N'-substituted-2-(5-(4-chlorophenyl)-1,3,4oxadiazol-2-ylthio)acetohydrazide, 8a-p, through a multistep synthesis of corresponding ester, 2, hydrazide, 3 and 1,3,4-oxadiazole, 4. The molecule, 4, was subjected to electrophil...

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The title compound, C(12)H(8)N(4)O(2)·C(8)H(6)O(4), was synthesized from 4-[5-(4-pyrid-yl)-1,3,4-oxadiazol-2-yl]pyridine N-oxide and isophthalic acid. The two mol-ecules are linked through O-H⋯O and O-H⋯N hydrogen bonds. Weak intra-molecular π-π inter-actions between the two hydrogen-bonded chains result in the formation a one-dimensional supra-molecular curved tape (the face-to-face distance b...

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N-(4-Chloro­phen­yl)-1-(5-{[(2-phenyl­ethen­yl)sulfon­yl]meth­yl}-1,3,4-oxadiazol-2-yl)methane­sulfonamide

In the title compound, C(18)H(16)ClN(3)O(5)S(2), the dihedral angles between the oxadiazole ring and the phenyl and chloro-benzene rings are 23.4 (2) and 45.4 (2)°, respectively. The C-S-N-C and C(ox)-C-S-C (ox = oxadiazole) torsion angles are 89.3 (5) and -69.1 (3)°, respectively. A short intra-molecular C-H⋯O contact closes an S(6) ring. In the crystal, mol-ecules are linked by N-H⋯O hydrogen...

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5-(4-Methyl­phen­yl)-1,3,4-oxadiazol-2-amine

In the crystal structure of the title compound, C(9)H(9)N(3)O, adjacent mol-ecules are linked through N-H⋯N hydrogen bonds into a three-dimensional network.

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(S)-N-{1-[5-(4-Chloro­benzyl­sulfanyl)-1,3,4-oxadiazol-2-yl]eth­yl}-4-methyl­benzene­sulfonamide

The title compound, C(18)H(18)ClN(3)O(3)S(2), adopts by folding the form of a distorted disc. Inter-planar angles are 29.51 (7) and 63.43 (7)° from the five-membered ring to the aromatic systems and 34.80 (6)° between these two latter rings. The absolute configuration was confirmed by determination of the Flack parameter. In the crystal, the mol-ecules are linked by four hydrogen bonds, one cla...

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ژورنال

عنوان ژورنال: Acta Crystallographica Section E Structure Reports Online

سال: 2012

ISSN: 1600-5368

DOI: 10.1107/s1600536812037300